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TMR Integrative Nursing  2017, Vol. 1 Issue (2): 6-11    DOI: 10.12032/TMRIN20171202
    
Early enteral nutrition supplemented with probiotics improved the clinical outcomes in patients with severe head injury: protocol for a meta-analysis of randomized controlled trials
Li-Juan Yi a#, Xu Tian b,c#, Wei-Qing Chen b#, Li Ma d, Huan He b, Hui Chen b, Cheng-Xiang Wu a*, Yuan-Ping Pie*
a Department of Nursing, Hunan Traditional Chinese Medical College, Zhuzhou 412012, China. b Department of Gastroenterology, Chongqing Cancer Institute & Hospital & Cancer Center/Chongqing University Cancer Hospital, Chongqing 400030, China. c Editorial Office, TMR Integrative Nursing, TMR Publishing Group, Tianjin 300170, China. d Department of Nursing, Guizhou Medical University, Guizhou 550025, China. e Department of Nursing, Chongqing Cancer Institute & Hospital & Cancer Center/Chongqing University Cancer Hospital, Chongqing 400030, China.
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Abstract  Objective: The aim of this systematic review of randomized controlled trials (RCTs) is to determine the effects of early enteral nutrition supplemented with probiotics on clinical outcomes in patients with SHI.
Methods and analysis: A systematic search will be carried out in PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), China National Knowledge Infrastructure (CNKI), WanFang database, and Chinese Biomedical Literature (CBM) in order to identify the randomized controlled trials (RCTs) investigated the potential of early enteral nutrition supplemented with probiotics on patients with severe head injury, as well as we will also manually check the bibliographies of eligible studies and topic-related reviews. We will assign two investigators to independently search all potential citations, extracted data, and appraised risk of bias accordingly, and then STATA software version 12.0 will be used to statistically analyze all data.
Ethics and dissemination: The ethics approval and patient written informed consent will not be required because all analyses in the present study will be performed based on data from published studies. We will submit our systematic review to a peer-reviewed scientific journal for publication.


Highlights  Clinical trials have shown that early enteral nutrition supplemented with probiotics may have potential of benefit for SHI patients; however, conflicting conclusion obstacle the decision-making. This protocol will provide approach to resolve this issue.
Key wordsServer head injury      Enteral nutrition      Probiotics      Meta-analysis      Research protocol     
Published: 25 December 2017
Corresponding Authors: Cheng-Xiang Wu, Department of Nursing, Hunan Traditional Chinese Medical College, NO.136, Lusong Road, Lusong District, Zhuzhou 412000, China. E-mail address: 529875790@qq.com. Yuan-Ping Pi, Department of Nursing, Chongqing Cancer Institute & Hospital & Cancer Center/Chongqing University Cancer Hospital, NO.181 Hanyu Road, Shapingba District, Chongqing 400030, China. E-mail address: cqzlyyhlb@163.com.   
Cite this article:

Li-Juan Yi, Xu Tian, Wei-Qing Chen, Li Ma, Huan He, Hui Chen, Cheng-Xiang Wu, Yuan-Ping Pi. Early enteral nutrition supplemented with probiotics improved the clinical outcomes in patients with severe head injury: protocol for a meta-analysis of randomized controlled trials. TMR Integrative Nursing, 2017, 1(2): 6-11.

URL:

http://www.tmrnursing.com/10.12032/TMRIN20171202     OR     http://www.tmrnursing.com/Y2017/V1/I2/6

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