Objective: To identify and clarify the existing definitions of quality of life in head and neck cancer survivors. This concept analysis will inform healthcare professionals of promoting nursing care for head and neck cancer survivors and eventually improve their quality of life. Method: Concept analysis based on Walker and Avant’s framework. Results: Quality of life is a subjective and personally derived cognitive evaluation of global well-being by perceiving a feeling of overall life satisfaction in his/her own value, happiness, and the independence to manage daily activities and life experience. Three defining attributes for quality of life were identified: a feeling of overall life satisfaction in his/her value, global personal well-being, and independence. An improvement of quality of life means an improvement of clinical outcome. However, the variety of instruments for measuring life quality makes it difficult for healthcare professionals to select a standard one for head and neck cancer survivors. Conclusion: By proposing a comprehensive definition of the concept, this analysis contributes to the advancement of knowledge about quality of life in the context of head and neck cancer survivorship. Through a sound understanding of the phenomenon, healthcare professions will recognize or measure head and neck cancer survivors’ life conditions in a more accurate way and to implement intervention where necessary, eventually, improve patients’ life quality in survivorship.